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1993 1
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32 results

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Page 1
Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency.
Balasubramanian R, Crowley WF Jr. Balasubramanian R, et al. 2007 May 23 [updated 2022 May 12]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2007 May 23 [updated 2022 May 12]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301509 Free Books & Documents. Review.
Prevention of secondary complications: Optimal calcium and vitamin D intake should be encouraged and specific treatment for decreased bone mass as needed. Surveillance: For children of both sexes with findings suggestive of IGD, monitor at regular intervals after age 11 ye …
Prevention of secondary complications: Optimal calcium and vitamin D intake should be encouraged and specific treatment for decreased bon …
Lactational Amenorrhea: Neuroendocrine Pathways Controlling Fertility and Bone Turnover.
Calik-Ksepka A, Stradczuk M, Czarnecka K, Grymowicz M, Smolarczyk R. Calik-Ksepka A, et al. Int J Mol Sci. 2022 Jan 31;23(3):1633. doi: 10.3390/ijms23031633. Int J Mol Sci. 2022. PMID: 35163554 Free PMC article. Review.
Despite the decline in bone mass during breastfeeding, it rebuilds after weaning and is not associated with a postmenopausal decrease in BMD and osteoporosis risk. ...We also review the literature on the topic of lactational bone loss: its mechanism, severity, and p …
Despite the decline in bone mass during breastfeeding, it rebuilds after weaning and is not associated with a postmenopausal decrease …
Central precocious puberty, functional and tumor-related.
Soriano-Guillén L, Argente J. Soriano-Guillén L, et al. Best Pract Res Clin Endocrinol Metab. 2019 Jun;33(3):101262. doi: 10.1016/j.beem.2019.01.003. Epub 2019 Jan 22. Best Pract Res Clin Endocrinol Metab. 2019. PMID: 30733078 Review.
However, in the last decade the number of idiopathic cases has diminished thanks to the discovery of mutations in different genes, including KISS1, KISS1R, MKRN3, and DLK1 that cause CPP. For the diagnosis of CPP, hormone studies are needed in addition to the clinical data …
However, in the last decade the number of idiopathic cases has diminished thanks to the discovery of mutations in different genes, including …
Should We Make More Bone or Not, As Told by Kisspeptin Neurons in the Arcuate Nucleus.
Herber CB, Ingraham HA. Herber CB, et al. Semin Reprod Med. 2019 May;37(3):147-150. doi: 10.1055/s-0039-3400238. Epub 2019 Dec 23. Semin Reprod Med. 2019. PMID: 31869843 Free PMC article. Review.
Kiss1 expression is highly responsive to fluctuations of the gonadal hormone, estrogen, with nearly 90% of Kiss1(ARC) neurons expressing the nuclear hormone estrogen receptor alpha (ERa). Here we review recent research that extends the function of Kiss1ARC neurons b …
Kiss1 expression is highly responsive to fluctuations of the gonadal hormone, estrogen, with nearly 90% of Kiss1(ARC) neurons …
Brain-Derived CCN3 Is An Osteoanabolic Hormone That Sustains Bone in Lactating Females.
Babey ME, Krause WC, Herber CB, Chen K, Nikkanen J, Rodriquez R, Zhang X, Castro-Navarro F, Wang Y, Villeda S, Lane NE, Scheller EL, Chan CKF, Ambrosi TH, Ingraham HA. Babey ME, et al. bioRxiv [Preprint]. 2023 Nov 16:2023.08.28.554707. doi: 10.1101/2023.08.28.554707. bioRxiv. 2023. PMID: 37693376 Free PMC article. Preprint.
Here, we report that brain-derived CCN3 (Cellular Communication Network factor 3) secreted from KISS1 neurons of the arcuate nucleus (ARC (KISS1) ) fills this void and functions as a potent osteoanabolic factor to promote bone mass in lactating females. Using …
Here, we report that brain-derived CCN3 (Cellular Communication Network factor 3) secreted from KISS1 neurons of the arcuate nucleus …
Indirubin-3'-oxime promotes the efficacy of GnRHa in obese-induced central precocious puberty and maintains normal bone growth and body weight via the ERK-Sp1-KISS-1/GPR54 axis.
Jiang C, Qi L, Xue J, Wang Y. Jiang C, et al. Cell Mol Biol (Noisy-le-grand). 2023 Apr 30;69(4):188-194. doi: 10.14715/cmb/2023.69.4.29. Cell Mol Biol (Noisy-le-grand). 2023. PMID: 37329527
And, I3O could significantly eliminate the role of growth deceleration of GnRHa in bone development and reversed the side effect of GnRHa on body weight. ...In summary, these data indicated that I3O could promote the efficacy of GnRHa in HFD-induced precocious puberty, and …
And, I3O could significantly eliminate the role of growth deceleration of GnRHa in bone development and reversed the side effect of G …
Long non-coding RNA MNX1-AS1 promoted osteosarcoma proliferation and invasion via inhibiting KISS1.
Zhang YX, Cui HX, Liu L, Yi GK. Zhang YX, et al. Eur Rev Med Pharmacol Sci. 2019 Jul;23(14):6045-6052. doi: 10.26355/eurrev_201907_18417. Eur Rev Med Pharmacol Sci. 2019. PMID: 31364121 Free article. Retracted.
The abilities of proliferation and invasion were suppressed after MNX1-AS1 was knocked down in vitro. Moreover, KISS1 expression was upregulated at mRNA and protein level via silence of MNX1-AS1. ...CONCLUSIONS: Our study demonstrated that MNX1-AS1 could enhance osteosarco …
The abilities of proliferation and invasion were suppressed after MNX1-AS1 was knocked down in vitro. Moreover, KISS1 expression was …
KiSS1 inhibits growth and invasion of osteosarcoma cells through inhibition of the MAPK pathway.
Zhang Y, Tang YJ, Li ZH, Pan F, Huang K, Xu GH. Zhang Y, et al. Eur J Histochem. 2013 Oct 29;57(4):e30. doi: 10.4081/ejh.2013.e30. Eur J Histochem. 2013. PMID: 24441183 Free PMC article.
As a metastasis suppressor, KiSS1 has been implicated in numerous human cancers. However, recent studies have demonstrated that KiSS1 promotes tumor growth and metastasis in breast cancer, and it is unclear about the expression and function of KiSS1 in human …
As a metastasis suppressor, KiSS1 has been implicated in numerous human cancers. However, recent studies have demonstrated that Ki …
Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.
Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA. Herber CB, et al. Nat Commun. 2019 Jan 11;10(1):163. doi: 10.1038/s41467-018-08046-4. Nat Commun. 2019. PMID: 30635563 Free PMC article.
Here, we ablate estrogen receptor alpha (ERalpha) in the medial basal hypothalamus and find a robust bone phenotype only in female mice that results in exceptionally strong trabecular and cortical bones, whose density surpasses other reported mouse models. ...Loss o …
Here, we ablate estrogen receptor alpha (ERalpha) in the medial basal hypothalamus and find a robust bone phenotype only in female mi …
Mutational analysis of KISS1 and KISS1R in idiopathic central precocious puberty.
Krstevska-Konstantinova M, Jovanovska J, Tasic VB, Montenegro LR, Beneduzzi D, Silveira LF, Gucev ZS. Krstevska-Konstantinova M, et al. J Pediatr Endocrinol Metab. 2014 Jan;27(1-2):199-201. doi: 10.1515/jpem-2013-0080. J Pediatr Endocrinol Metab. 2014. PMID: 23950571
Luteinizing hormone-releasing hormone test was performed in all subjects, and all of them had a pubertal response (LH 20.3532.37 mIU/mL; FSH 23.3215.72 mIU/mL). The coding regions of KISS1 and KISS1R were sequenced. RESULTS: No rare variants were detected in KISS1 o …
Luteinizing hormone-releasing hormone test was performed in all subjects, and all of them had a pubertal response (LH 20.3532.37 mIU/mL; FSH …
32 results